Analysis of three characterization assays reveals ddPCR of LIN28A as the most sensitive for the detection of residual pluripotent stem cells in cellular therapy products

Author:

Sun JindaORCID,Yates ClarissaORCID,Dingwall Steve,Ongtengco Cherica,Power Dominique,Gray Peter,Prowse AndrewORCID

Publisher

Elsevier BV

Reference29 articles.

1. Pluripotent stem cell-based cell therapy—promise and challenges;Yamanaka;Cell Stem Cell,2020

2. Progress in stem cells-based replacement therapy for retinal pigment epithelium: in vitro differentiation to in vivo delivery;Gupta;Stem Cells Translat Med,2023

3. Cellular heterogeneity of pluripotent stem cell-derived cardiomyocyte grafts is mechanistically linked to treatable arrhythmias;Selvakumar;Nature Cardiovasc Res,2024

4. Transplanting neural progenitor cells to restore connectivity after spinal cord injury;Fischer;Nature Rev Neurosci,2020

5. (US)NLoM, Autologous transplantation of induced pluripotent stem cell-derived retinal pigment epithelium for geographic atrophy associated with age-related macular degeneration. 2020. https://clinicaltrials.gov/study/NCT04339764. [accessed 18.12.2023].

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