Defective WNT signaling may protect from articular cartilage deterioration – a quantitative MRI study on subjects with a heterozygous WNT1 mutation

Author:

Lehtovirta S.,Mäkitie R.E.,Casula V.,Haapea M.,Niinimäki J.,Niinimäki T.,Peuna A.,Lammentausta E.,Mäkitie O.,Nieminen M.T.

Funder

Sigrid Jusélius Foundation

Folkhälsan Research Foundation

Academy of Finland

Foundation for Pediatric Research

Helsinki University Research Funds

University of Helsinki

Helsinki University Hospital

Swedish Research Council

Novo Nordisk Foundation

Jane and Aatos Erkko foundation

Publisher

Elsevier BV

Subject

Orthopedics and Sports Medicine,Biomedical Engineering,Rheumatology

Reference66 articles.

1. Wnt signaling in bone development and disease: making stronger bone with Wnts;Regard;Cold Spring Harb Perspect Biol,2012

2. Induction of canonical Wnt signaling by synovial overexpression of selected wnts leads to protease activity and early osteoarthritis-like cartilage damage;van den Bosch;Am J Pathol,2015

3. Loss of sclerostin promotes osteoarthritis in mice via beta-catenin-dependent and -independent Wnt pathways;Bouaziz;Arthritis Res Ther,2015

4. Low-density lipoprotein receptor-related protein 5 governs Wnt-mediated osteoarthritic cartilage destruction;Shin;Arthritis Res Ther,2014

5. Wnt-related genes and large-joint osteoarthritis: association study and replication;Garcia-Ibarbia;Rheumatol Int,2013

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