IL6 receptor blockade preserves articular cartilage and increases bone volume following ischemic osteonecrosis in immature mice

Author:

Kamiya N.ORCID,Kuroyanagi G.,Aruwajoye O.,Kim H.K.W.

Funder

Genentech

Texas Scottish Rite Hospital for Children

JPJS KAKENHI

Publisher

Elsevier BV

Subject

Orthopedics and Sports Medicine,Biomedical Engineering,Rheumatology

Reference37 articles.

1. Legg-Calve-Perthes disease: etiology, pathogenesis, and biology;Kim;J Pediatr Orthop,2012

2. Osteoarthritis of the young adult hip: etiology and treatment;Aronson;Instr Course Lect,1986

3. Significance of synovitis in Legg-Calve-Perthes disease;Wingstrand;J Pediatr Orthop B,1999

4. Legg-Calve-Perthes disease produces chronic hip synovitis and elevation of interleukin-6 in the synovial fluid;Kamiya;J Bone Miner Res,2015

5. HIF-1-Dependent IL-6 activation in articular chondrocytes initiating synovitis in femoral head ischemic osteonecrosis;Yamaguchi;J Bone Joint Surg Am,2016

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