Lumican is upregulated in osteoarthritis and contributes to TLR4-induced pro-inflammatory activation of cartilage degradation and macrophage polarization

Author:

Barreto G.,Senturk B.,Colombo L.,Brück O.,Neidenbach P.,Salzmann G.,Zenobi-Wong M.,Rottmar M.ORCID

Funder

Center for Biotechnology and Molecular Medicine

Publisher

Elsevier BV

Subject

Orthopedics and Sports Medicine,Biomedical Engineering,Rheumatology

Reference51 articles.

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2. Updated estimates suggest a much higher prevalence of arthritis in United States adults than previous ones;Jafarzadeh;Arthritis Rheum,2018

3. The role of innate immunity in osteoarthritis: when our first line of defense goes on the offensive;Orlowsky;J Rheumatol,2015

4. Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!);Berenbaum;Osteoarthr Cartil,2013

5. Synovium and the innate inflammatory network in osteoarthritis progression;Liu-Bryan;Curr Rheumatol Rep,2013

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