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Can we target CCR2 to treat osteoarthritis? The trick is in the timing!

  • Published:2017-06 Issue:6 Volume:25 Page:799-801
  • ISSN:1063-4584
  • Container-title:Osteoarthritis and Cartilage
  • language:en
  • Short-container-title:Osteoarthritis and Cartilage

Author:

Miller R.E.,Malfait A.-M.ORCID

Funder

US National Institutes of Health/National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIH/NIAMS)

Publisher

Elsevier BV

Subject

Orthopedics and Sports Medicine,Biomedical Engineering,Rheumatology

Reference15 articles.

1. The many roles of chemokines and chemokine receptors in inflammation;Charo;N Engl J Med,2006

2. CCL2-CCR2 signaling in disease pathogenesis;O'Connor;Endocr Metab Immune Disord Drug Targets,2015

3. CCR1 and CCR2 antagonists;Zimmermann;Curr Top Med Chem,2014

4. Chemokines and inflammation in osteoarthritis: insights from patients and animal models;Scanzello;J Orthop Res,2016

5. Depletion of protease-activated receptor 2 but not protease-activated receptor 1 may confer protection against osteoarthritis in mice through extracartilaginous mechanisms;Jackson;Arthritis Rheumatol,2014
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