Prostaglandin D2 is a novel repressor of IFNγ induced indoleamine-2,3-dioxygenase via the DP1 receptor and cAMP pathway

Author:

Bassal Nesrine Kamal,Hughes Bernard P,Costabile Maurizio

Funder

University of South Australia Research Leadership Program

Publisher

Elsevier BV

Subject

Cell Biology,Clinical Biochemistry

Reference42 articles.

1. Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase;Uyttenhove;Nat. Med.,2003

2. Mechanism of interferon-gamma action. Characterization of indoleamine 2,3-dioxygenase in cultured human cells induced by interferon-gamma and evaluation o the enzyme-mediated tryptophan degradation in it s anticellular activity;Takikawa;J. Biol. Chem.,1988

3. Tryptophan-derived catabolites are responsible for inhibition of T and natural killer cell proliferation induced by indoleamine 2,3-dioxygenase;Frumento;J. Exp. Med.,2002

4. GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase;Munn;Immunity,2005

5. The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T cell receptor zeta-chain and induce a regulatory phenotype in naïve T cells;Fallarino;J. Immunol.,2006

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