PD-1/PD-L1 inhibitor monotherapy or in combination with chemotherapy as upfront treatment for advanced NSCLC with PD-L1 expression ≥ 50%: Selecting the best strategy

Author:

Di Federico AlessandroORCID,De Giglio AndreaORCID,Parisi Claudia,Gelsomino Francesco,Ardizzoni Andrea

Funder

Pfizer

Celgene

Publisher

Elsevier BV

Subject

Oncology,Hematology

Reference25 articles.

1. Outcomes to first-line pembrolizumab in patients with non-small-cell lung cancer and very high PD-L1 expression;Aguilar;Ann. Oncol.,2019

2. Pembrolizumab plus ipilimumab or placebo for metastatic non-small-cell lung cancer with PD-L1 tumor proportion score ≥ 50%: randomized, double-blind phase III KEYNOTE-598 study;Boyer;J. Clin. Oncol.,2021

3. LBA51 KEYNOTE-024 5-year OS update: first-line (1L) pembrolizumab (pembro) vs platinum-based chemotherapy (chemo) in patients (pts) with metastatic NSCLC and PD-L1 tumour proportion score (TPS) ≥50%;Brahmer;Ann. Oncol.,2020

4. First-line nivolumab in stage IV or recurrent non-small-cell lung cancer;Carbone;N. Engl. J. Med.,2017

5. Abstract CT084: Relationship Between STK11 and KEAP1 Mutational Status and Efficacy in KEYNOTE-042: Pembrolizumab Monotherapy Versus Platinum-Based Chemotherapy as First-Line Therapy for PD-L1-Positive Advanced NSCLC;Cho,2020

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