Design, synthesis and biological activity of cyclohexane-bearing C-glucoside derivatives as SGLT2 inhibitors

Author:

Zhang Shuo,Wang Yu-Li,Wei Qun-Chao,Xu Wei-Ren,Tang Li-Da,Zhao Gui-Long,Wang Jian-Wu

Publisher

Elsevier BV

Subject

General Chemistry

Reference6 articles.

1. Discovery of dapagliflozin: a potent, selective renal sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes;Meng;J. Med. Chem.,2008

2. Development of the renal glucose reabsorption inhibitors: a new mechanism for the pharmacotherapy of diabetes mellitus type 2;Washburn;J. Med. Chem.,2009

3. Design, synthesis and antihyperglycemic activity of trans-cyclohexane-bearing C-glucosides as SGLT2 inhibitors;Shao;Chin. J. Org. Chem.,2011

4. Synthesis and anti-hyperglycemic activities of trans-cyclohexane-bearing C-glucosides as SGLT2 inhibitors II;Zhao;Chin. J. Synth. Chem.,2012

5. Synthesis of an antimetastatic tetrasaccharide β-d-Gal-(1→4)-β-d-GlcpNAc-(1→6)-α-d-Manp-(1→6)-β-d-Manp-OMe;Liao;Chin. Chem. Lett.,2012

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