Impaired drug uptake in methotrexate resistant Crithidia fasciculata without changes in dihydrofolate reductase activity or gene amplification

Author:

Dewes Homero,Ostergaard Hanne L.,Simpson Larry

Publisher

Elsevier BV

Subject

Molecular Biology,Parasitology

Reference45 articles.

1. The chemotherapy of trypanosome infections;Browning;Ann. N.Y. Acad. Sci.,1954

2. Drug resistance in trypanosomiasis and leishmaniasis;Peters,1974

3. Drug-resistant Leptomonas: cross-resistance in trypanocide- resistant clones;Bacchi;Antimicrob. Agents Chemother.,1975

4. Isolation and characterization of drug resistant mutants of Crithidia fasciculata;Hughes;J. Parasitol.,1982

5. Overproduction of a bifunctional thymidylate synthetase-dihydrofolate reductase and DNA amplification in methotrexate-resistant Leishmania tropica;Coderre,1983

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