Recombinant Plasmodium falciparum dihydrofolate reductase-based in vitro screen for antifolate antimalarials

Author:

Brobey Reynolds K.B.,Sano Gen-ichiro,Itoh Fumio,Aso Kazuyoshi,Kimura Masatsugu,Mitamura Toshihide,Horii Toshihiro

Publisher

Elsevier BV

Subject

Molecular Biology,Parasitology

Reference36 articles.

1. Altered dihydrofolate reductase in pyrimethamine resistant Plasmodium falciparum;Walter;Mol. Biochem. Parasitol.,1986

2. Kinetic and molecular properties of the dihydrofolate reductase from pyrimethamine sensitive and pyrimethamine resistant clones of the human malaria parasite Plasmodium falciparum;Chen;Mol. Pharmacol.,1987

3. Evidence that a point mutation in dihydrofolate reductase-thymidylate synthase confers resistance to pyrimethamine in falciparum malaria;Peterson,1988

4. Point mutations in the dihydrofolate reductase-thymidylate synthase gene and pyrimethamine and cycloguanil resistance in Plasmodium falciparum;Basco;Mol. Biochem. Parasitol.,1995

5. Point mutations in the dihydrofolate reductase-thymidylate synthase gene as a molecular basis for pyrimethamine resistance in Plasmodium falciparum;Zolg;Mol. Biochem. Parasitol.,1989

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