A multi-dataset time-reversal approach to clinical trial placebo response and the relationship to natural variability in epilepsy

Author:

Goldenholz Daniel M.,Strashny Alex,Cook Mark,Moss Robert,Theodore William H.

Funder

National Institute of Neurological Disorders and Stroke Division of Intramural Research

Publisher

Elsevier BV

Subject

Clinical Neurology,Neurology,General Medicine

Reference34 articles.

1. Early identification of refractory epilepsy;Kwan;N Engl J Med,2000

2. Institute of Medicine (U.S.), Committee on the Public Health Dimensions of the Epilepsies, England MJ. Epilepsy across the spectrum promoting health and understanding. Washington, D.C.: National Academies Press, 2012 http://www.nap.edu/catalog.php?record_id=13379 (Accessed 28 August 2014).

3. PhRMA. Profile Biopharmaceutical Research Industry. 2015 http://www.phrma.org/sites/default/files/pdf/2015_phrma_profile.pdf.

4. Factors determining response to antiepileptic drugs in randomized controlled trials. A systematic review and meta-analysis: Response to AEDs in Randomized Trials;Rheims;Epilepsia,2011

5. Response to placebo in clinical epilepsy trials-old ideas and new insights;Goldenholz;Epilepsy Res,2016

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