1-ethylazacycloalkan-2-one indomethacin esters as new oral prodrugs: chemical stability, enzymatic hydrolysis, anti-inflammatory activity and gastrointestinal toxicity

Author:

Bonina Francesco,Trombetta Domenico,Borzi' Antonella,De Pasquale Anna,Saija Antonella

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference21 articles.

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2. Ulcerogenicity and effect on inhibition of prostaglandin generation of indometacin farnesil, a prodrug of indomethacin, in rat gastric mucosa: comparison with indomethacin or loxoprofen;Arakawa;Drugs Exp. Clin. Res.,1995

3. Effect of group substitution on the physicochemical properties of ibuprofen prodrugs;Bansal;Pharmazie,1994

4. 1-alkylazacycloalkan-2-one esters as prodrugs of indomethacin for improved delivery through human skin;Bonina;Int. J. Pharm.,1991

5. Pharmacokinetic and pharmacodynamic profile of triethylene glycol indomethacin ester as a new oral prodrug;Bonina;J. Control. Release,1996

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