Prediction of plasma concentration–time curve of orally administered theophylline based on a scintigraphic monitoring of gastrointestinal transit in human volunteers

Author:

Haruta Shunji,Kawai Keiichi,Nishii Ryuichi,Jinnouchi Seishi,Ogawara Ken-ichi,Higaki Kazutaka,Tamura Shozo,Arimori Kazuhiko,Kimura Toshikiro

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference23 articles.

1. Estimating human oral fraction dose absorbed: a correlation using rat intestinal membrane permeability for passive and carrier-mediated compounds;Amidon;Pharm. Res.,1988

2. Method for monitoring hard gelatin capsule disintegration times in humans using external scintigraphy;Casey;J. Pharm. Sci.,1976

3. Transit of pharmaceutical dosage forms through the small intestine;Davis;Gut,1986

4. Gamma scintigraphy and neutron activation techniques in the vivo assessment of orally administered dosage forms;Digenis;Crit. Revs. Ther. Drug Carrier Syst.,1991

5. Gamma scintigrapy: an evolving technology in pharmaceutical formulation development—Part 1;Digenis;Pharm. Sci. Technol. Today,1998

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