Substitution of glutamate-3, valine-19, leucine-23, and serine-24 with alanine in the N-terminal region of human heart muscle carnitine palmitoyltransferase I abolishes malonyl CoA inhibition and binding-Reference-Cited by-同舟云学术

Substitution of glutamate-3, valine-19, leucine-23, and serine-24 with alanine in the N-terminal region of human heart muscle carnitine palmitoyltransferase I abolishes malonyl CoA inhibition and binding

Published:2003-05 Issue:1 Volume:413 Page:67-74
ISSN:0003-9861
Container-title:Archives of Biochemistry and Biophysics
language:en
Short-container-title:Archives of Biochemistry and Biophysics

Author:

Zhu Hongfa,Shi Jianying,Treber Michelle,Dai Jia,Arvidson Dennis N,Woldegiorgis Gebre

Publisher

Elsevier BV

Subject

Molecular Biology,Biochemistry,Biophysics

Reference29 articles.

1. CARNITINE

2. The Mitochondrial Carnitine Palmitoyltransferase System - From Concept to Molecular Analysis

3. Rat heart expresses two forms of mitochondrial carnitine palmitoyltransferase I. The minor component is identical to the liver enzyme.

4. Use of a selective inhibitor of liver carnitine palmitoyltransferase I (CPT I) allows quantification of its contribution to total CPT I activity in rat heart. Evidence that the dominant cardiac CPT I isoform is identical to the skeletal muscle enzyme

5. Mitochondrial Carnitine Palmitoyltransferase I Isoform Switching in the Developing Rat Heart

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2. Molecular characterization, tissue distribution and kinetic analysis of carnitine palmitoyltransferase I in juvenile yellow catfish Pelteobagrus fulvidraco;Genomics;2013-03

3. Genome duplication events have led to a diversification in the CPT I gene family in fish;American Journal of Physiology-Regulatory, Integrative and Comparative Physiology;2010-08

4. Replacement of C305 in Heart/Muscle-Type Isozyme of Human Carnitine Palmitoyltransferase I with Aspartic Acid and Other Amino Acids;Biochemical Genetics;2009-11-25

5. A characteristic Glu17 residue of pig carnitine palmitoyltransferase 1 is responsible for the low Km for carnitine and the low sensitivity to malonyl-CoA inhibition of the enzyme;FEBS Journal;2008-11-25