Chapter 9 Quantification and structural elucidation of low quantities of radiolabeled metabolites using microplate scintillation counting (msc) techniques in conjunction with lc-ms

Author:

Zhu Mingshe,Zhang Donglu,Skiles Gary L.

Publisher

Elsevier

Reference35 articles.

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2. Optimizing drug development: strategies to assess drug metabolism/transporter interaction potential-toward a consensus;Tucker;Clin. Pharm. Ther.,2001

3. The European Agency for the Evaluation of Medicinal Products: Human Medicines Evaluation Unit, 1997. Note for Guidance on the Investigation of Drug Interactions. (CPMP/EW/560/95).

4. Contemporary issues in toxicology: drug metabolites in safety testing;Baillie;Toxicol. Appl. Pharm.,2002

5. Radiochemical high-performance liq-uid Chromatographic assay for the determination of catechol O-methyltransferase activity towards various substrates;Lautala;J. Chromatogr. B,1999

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