2-Methoxymethylestradiol: a new 2-methoxy estrogen analog that exhibits antiproliferative activity and alters tubulin dynamics

Author:

Brueggemeier Robert W,Bhat Abhijit S,Lovely Carl J,Coughenour Holly D,Joomprabutra Surachai,Weitzel Douglas H,Vandre Dale D,Yusuf Fouza,Burak William E

Publisher

Elsevier BV

Subject

Cell Biology,Clinical Biochemistry,Endocrinology,Molecular Biology,Molecular Medicine,Biochemistry,Endocrinology, Diabetes and Metabolism

Reference31 articles.

1. American Cancer Society, Cancer Facts and Figures, 1999.

2. The endogenous oestrogen metabolite 2-methoxyoestradiol inhibits angiogenesis and suppresses tumour growth;Fotsis;Nature,1994

3. 2-Methoxyestradiol, an endogenous mammalian metabolite, inhibits tubulin polymerization by interacting at the colchicine site;D'Amato;Proc. Natl. Acad. Sci.,1994

4. Interactions of 2-methoxyestradiol, an endogenous mammalian metabolite, with unpolymerized tubulin and with tubulin dimers;Hamel;Biochemistry,1996

5. Inhibition of angiogenesis and breast cancer in mice by the microtubule inhibitors 2-methoxyestradiol and taxol;Klauber;Cancer Res.,1996

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