LKB1 Deficiency Renders NSCLC Cells Sensitive to ERK Inhibitors

Author:

Caiola Elisa,Iezzi Alice,Tomanelli Michele,Bonaldi Elisa,Scagliotti Arianna,Colombo Marika,Guffanti Federica,Micotti Edoardo,Garassino Marina Chiara,Minoli Lucia,Scanziani Eugenio,Broggini Massimo,Marabese Mirko

Funder

Associazione Italiana per la Ricerca sul Cancro

Publisher

Elsevier BV

Subject

Pulmonary and Respiratory Medicine,Oncology

Reference36 articles.

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2. Prevalence and specificity of LKB1 genetic alterations in lung cancers;Matsumoto;Oncogene,2007

3. The LKB1-AMPK pathway: metabolism and growth control in tumour suppression;Shackelford;Nat Rev Cancer,2009

4. The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress;Shaw;Proc Natl Acad Sci U S A,2004

5. LKB1: cancer, polarity, metabolism, and now fertility;Shaw;Biochem J,2008

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