Small Cell Lung Cancer Transformation as a Mechanism of Resistance to PD-1 Therapy in KRAS-Mutant Lung Adenocarcinoma: A Report of Two Cases

Author:

Iams Wade T.,Beckermann Kathryn E.,Almodovar Karinna,Hernandez Jennifer,Vnencak-Jones Cindy,Lim Lee P.,Raymond Christopher K.,Horn Leora,Lovly Christine M.

Funder

Pfizer

Novartis

Ariad

National Institutes of Health

National Cancer Institute

American Society of Clinical Oncology

Conquer Cancer Foundation

Vanderbilt-Ingram Cancer

LUNGevity

Lung Cancer Foundation of America

International Association for the Study of Lung Cancer

Cancer Research Institute

Lung Cancer Foundation

Publisher

Elsevier BV

Subject

Pulmonary and Respiratory Medicine,Oncology

Reference5 articles.

1. Clonal history and genetic predictors of transformation into small-cell carcinomas from lung adenocarcinomas;Lee;J Clin Oncol,2017

2. Transformation from non-small-cell lung cancer to small-cell lung cancer: molecular drivers and cells of origin;Oser;Lancet Oncol,2015

3. Small cell lung cancer transformation during immunotherapy with nivolumab: a case report;Imakita;Respir Med Case Rep,2017

4. Cell of origin of small cell lung cancer: inactivation of Trp53 and Rb1 in distinct cell types of adult mouse lung;Sutherland;Cancer Cell,2011

5. Small-cell carcinoma in the setting of pulmonary adenocarcinoma: new insights in the era of molecular pathology;Norkowski;J Thorac Oncol,2013

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