Updated Efficacy and Safety Data and Impact of the EML4-ALK Fusion Variant on the Efficacy of Alectinib in Untreated ALK-Positive Advanced Non–Small Cell Lung Cancer in the Global Phase III ALEX Study

Author:

Camidge D. Ross,Dziadziuszko Rafal,Peters Solange,Mok Tony,Noe Johannes,Nowicka Malgorzata,Gadgeel Shirish M.,Cheema Parneet,Pavlakis Nick,de Marinis Filippo,Cho Byoung Chul,Zhang Li,Moro-Sibilot Denis,Liu Ting,Bordogna Walter,Balas Bogdana,Müller Barbara,Shaw Alice T.

Funder

AstraZeneca

Bristol-Myers Squibb

Celgene

Genentech

Novartis

Merck Sharp and Dohme

Pfizer

Roche

F. Hoffmann-La Roche

Merck

Amgen

Merck KgA

AbbVie

Publisher

Elsevier BV

Subject

Pulmonary and Respiratory Medicine,Oncology

Reference16 articles.

1. Alectinib in crizotinib-refractory ALK-rearranged non-small-cell lung cancer: a phase II global study;Ou;J Clin Oncol,2016

2. Alectinib in ALK-positive, crizotinib-resistant, non-small-cell lung cancer: a single-group, multicentre, phase 2 trial;Shaw;Lancet Oncol,2016

3. Alectinib versus crizotinib in untreated ALK-positive non-small-cell lung cancer;Peters;N Engl J Med,2017

4. EML4-ALK variants: biological and molecular properties, and the implications for patients;Sabir;Cancers (Basel),2017

5. Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer;Soda;Nature,2007

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