Exploring the mechanism of compromised thermostability of aromatic l-amino acid decarboxylase from Bacillus atrophaeus through comparative molecular dynamics simulations

Author:

Zhang Heng,Cheng Yuanxin,Ge Qiongqiong,Yu Jinhai,Fu Guangcheng,Gao Yunfan,Wang Yu,Ye Yunhui,Du Jianquan,Jiao Qingcai,Liu Junzhong

Funder

National Key Research and Development Program of China

Publisher

Elsevier BV

Subject

Physical and Theoretical Chemistry,Condensed Matter Physics,Biochemistry

Reference61 articles.

1. Aromaticl-amino acid decarboxylase: A neglected and misunderstood enzyme;Berry;Neurochem. Res.,1996

2. Complex evolution of orthologous and paralogous decarboxylase genes;Sáenz-de-Miera;J. Evol. Biol.,2004

3. Aromatic l-amino acid decarboxylase: Biological characterization and functional role, General Pharmacology: The Vascular;Zhu;System,1995

4. Biochemical diagnosis of aromatic-L-amino acid decarboxylase deficiency (AADCD) by assay of AADC activity in plasma using liquid chromatography/tandem mass spectrometry;Civallero;Mol. Genet. Metab. Rep.,2022

5. The novel P330L pathogenic variant of aromatic amino acid decarboxylase maps on the catalytic flexible loop underlying its crucial role;Bisello;Cell. Mol. Life Sci.,2022

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