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Targeting lipid peroxidation and mitochondrial imbalance in Friedreich's ataxia

  • Published:2015-09 Issue: Volume:99 Page:344-350
  • ISSN:1043-6618
  • Container-title:Pharmacological Research
  • language:en
  • Short-container-title:Pharmacological Research

Author:

Abeti Rosella,Uzun Ebru,Renganathan IndhushriORCID,Honda Tadashi,Pook Mark A.,Giunti Paola

Funder

FARA and GoFar, A&C Simeone Foundation

European Union Seventh Framework Programme

National Institute for Health Research

University College London Hospitals

Biomedical Research Centre

Publisher

Elsevier BV

Subject

Pharmacology

Reference37 articles.

1. GAA repeat instability in Friedreich ataxia YAC transgenic mice;Al-Mahdawi;Genomics,2004

2. GAA repeat expansion mutation mouse models of Friedreich ataxia exhibit oxidative stress leading to progressive neuronal and cardiac pathology;Al-Mahdawi;Genomics,2006

3. Lipid peroxidation is essential for α-synuclein-induced cell death;Angelova;J Neurochem,2015

4. Frataxin acts as an iron chaperone protein to modulate mitochondrial aconitase activity;Bulteau;Science (New York, N.Y.),2004

5. Neurodegenerative diseases and oxidative stress;Barnham;Nat Rev Drug Discov,2004

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