Direct YAP/TAZ–TEAD inhibitor paves the way toward realizing cancer mechanomedicine

Author:

Papavassiliou Kostas A.,Gargalionis Antonios N.,Papavassiliou Athanasios G.

Publisher

Elsevier BV

Reference7 articles.

1. Direct and selective pharmacological disruption of the YAP-TEAD interface by IAG933 inhibits Hippo-dependent and RAS-MAPK-altered cancers;Chapeau;Nat. Cancer,2024

2. Direct inhibition of the YAP:TEAD interaction: an unprecedented drug discovery challenge;Chene;ChemMedChem,2024

3. The first class of small molecules potently disrupting the YAP-TEAD interaction by direct competition;Furet;ChemMedChem,2022

4. YAP/TAZ signaling and resistance to cancer therapy;Nguyen;Trends Cancer,2019

5. TEAD inhibition overcomes YAP1/TAZ-driven primary and acquired resistance to KRASG12C inhibitors;Edwards;Cancer Res,2023

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