Low Incidence of Off-Target Mutations in Individual CRISPR-Cas9 and TALEN Targeted Human Stem Cell Clones Detected by Whole-Genome Sequencing-Reference-Cited by-同舟云学术

Low Incidence of Off-Target Mutations in Individual CRISPR-Cas9 and TALEN Targeted Human Stem Cell Clones Detected by Whole-Genome Sequencing

Published:2014-07 Issue:1 Volume:15 Page:27-30
ISSN:1934-5909
Container-title:Cell Stem Cell
language:en
Short-container-title:Cell Stem Cell

Author:

Veres Adrian,Gosis Bridget S.,Ding Qiurong,Collins Ryan,Ragavendran Ashok,Brand Harrison,Erdin Serkan,Cowan Chad A.,Talkowski Michael E.,Musunuru Kiran

Publisher

Elsevier BV

Subject

Cell Biology,Genetics,Molecular Medicine

Reference21 articles.

1. Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease;Cho;Nat. Biotechnol.,2013

2. Analysis of off-target effects of CRISPR/Cas-derived RNA-guided endonucleases and nickases;Cho;Genome Res.,2014

3. Multiplex genome engineering using CRISPR/Cas systems;Cong;Science,2013

4. CRISPR/Cas9 systems targeting β-globin and CCR5 genes have substantial off-target activity;Cradick;Nucleic Acids Res.,2013

5. A TALEN genome-editing system for generating human stem cell-based disease models;Ding;Cell Stem Cell,2013

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