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Targeting of pegylated liposomal mitomycin-C prodrug to the folate receptor of cancer cells: Intracellular activation and enhanced cytotoxicity

  • Published:2016-03 Issue: Volume:225 Page:87-95
  • ISSN:0168-3659
  • Container-title:Journal of Controlled Release
  • language:en
  • Short-container-title:Journal of Controlled Release

Author:

Patil Yogita,Amitay Yasmine,Ohana Patricia,Shmeeda Hilary,Gabizon Alberto

Funder

Israel Cancer Research FundIsrael Cancer Research Fund

Lipomedix Pharmaceuticals Ltd.

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference50 articles.

1. Mitomycin C: a review;Crooke;Cancer Treat. Rev.,1976

2. The role of mitomycin antibiotics in the chemotherapy of solid tumors;Sartorelli;Biochem. Pharmacol.,1986

3. The mitomycin bioreductive antitumor agents: cross-linking and alkylation of DNA as the molecular basis of their activity;Tomasz;Pharmacol. Ther.,1997

4. Mitomycin C: a prototype bioreductive agent;Sartorelli;Oncol. Res.,1993

5. Mitomycin C inhibits ribosomal RNA: a novel cytotoxic mechanism for bioreductive drugs;Snodgrass;J. Biol. Chem.,2010

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