An age-related reduction of brain TBPH/TDP-43 levels precedes the onset of locomotion defects in a Drosophila ALS model

Author:

Cragnaz L.,Klima R.,De Conti L.,Romano G.,Feiguin F.,Buratti E.,Baralle M.,Baralle F.E.

Funder

TARMA

Thierry Latran Foundation

Publisher

Elsevier BV

Subject

General Neuroscience

Reference21 articles.

1. TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis;Arai;Biochem Biophys Res Commun,2006

2. Synapsin-dependent development of glutamatergic synaptic vesicles and presynaptic plasticity in postnatal mouse brain;Bogen;Neuroscience,2009

3. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes;Brand;Development,1993

4. Cellular model of TAR DNA-binding protein 43 (TDP-43) aggregation based on its C-terminal Gln/Asn-rich region;Budini;J Biol Chem,2012

5. TDP-43 loss of cellular function through aggregation requires additional structural determinants beyond its C-terminal Q/N prion-like domain;Budini;Human Mol Genet,2014

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