A semi-automated hybrid HPLC-MS approach for in-depth characterization of intact non-covalent heterodimer glycoforms of gonadotropin biopharmaceuticals

Author:

Di Marco Fiammetta,Blümel Gabriele,Blöchl ConstantinORCID,Wuhrer Manfred,Huber Christian G.ORCID

Publisher

Elsevier BV

Subject

Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

Reference50 articles.

1. Biological functions of hCG and hCG-related molecules;Cole;Reprod. Biol. Endocrinol.,2010

2. Gonadotropins and their analogs: current and potential clinical applications;Anderson;Endocr. Rev.,2018

3. The gonadotropins FSH and LH and their use in adult women an overviewbr(joint statement by the German society for gynecological endocrinology and reproductive medicine [DGGEF] and the German professional association of gynecologists [BVF]);Bachmann;J. Für Reproduktionsmedizin Und Endokrinol. - J. Reprod. Med. Endocrinol.,2015

4. Exploring the chemical space of protein glycosylation in noncovalent protein complexes: an expedition along different structural levels of human chorionic gonadotropin by employing mass spectrometry;Lebede;Anal. Chem.,2021

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