Pre-clinical toxicity of Il-4: A model for studying protein therapeutics

Author:

Dean Jack H.,Cornacoff Joel B.,Barbolt Thomas A.,Gossett Kent A.,LaBrie Teresa

Publisher

Elsevier BV

Subject

Pharmacology,Immunology

Reference13 articles.

1. Histomorphologic observations for cynomolgus monkeys after subcutaneous injection of recombinant human interleukin-4;Barbolt;Toxic. Path.,1991

2. IL-4 production by T cells from naive donors. IL-2 is required for IL-4 production;Ben-Sasson;J. Immun.,1990

3. Subchronic one-month safety evaluation of recombinant human interleukin-4 administered subcutaneously to monkeys;Cornacoff;Immunotherapy,1991

4. Lymphokine control of in vivo immunoglobulin isotype selection;Finkelman;A. Rev. Immun.,1990

5. Clinical pathologic alterations associated with subcutaneous administration of recombinant human interleukin-4 in cynomolgus monkeys;Gossett;Lab. Invest.,1991

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2. Immunotoxicology assessment in the pharmaceutical industry;Toxicology Letters;1998-12

3. Safety Evaluation and Risk Assessment Using Immunotoxicology Methods;International Journal of Toxicology;1998-04

4. Interleukin-4;Cytokines;1998

5. Safety Evaluation of Recombinant Human Interleukin-4;Clinical Immunology and Immunopathology;1997-04

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