Activin A targets extrasynaptic NMDA receptors to ameliorate neuronal and behavioral deficits in a mouse model of Huntington disease

Author:

Nassrallah Wissam B.,Ramandi Daniel,Cheng Judy,Oh Jean,Mackay James,Sepers Marja D.,Lau David,Bading Hilmar,Raymond Lynn A.

Funder

Hereditary Disease Foundation

European Research Council

Canadian Institutes of Health Research

Deutsche Forschungsgemeinschaft

Universität Heidelberg

Publisher

Elsevier BV

Subject

Neurology

Reference46 articles.

1. Activin a directs striatal projection neuron differentiation of human pluripotent stem cells;Arber;Development,2015

2. Age-related mitochondrial alterations in brain and skeletal muscle of the YAC128 model of Huntington disease;Bečanović;NPJ Aging Mech. Dis.,2021

3. Striatal astrocytes shape behavioral flexibility via regulation of the glutamate transporter EAAT2;Boender;Biol. Psychiatry,2021

4. Differential synaptic and Extrasynaptic glutamate-receptor alterations in striatal medium-sized spiny neurons of aged YAC128 Huntington’s disease mice;Botelho;PLoS Curr.,2014

5. Post-injury nose-to-brain delivery of Activin a and SerpinB2 reduces brain damage in a mouse stroke model;Buchthal;Mol. Ther.,2018

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