Optimizing intracellular antibodies (intrabodies/nanobodies) to treat neurodegenerative disorders

Author:

Messer Anne,Butler David C.

Funder

National Institutes of Health

Hereditary Disease Foundation

National Parkinson's Foundation

Parkinson's Disease Foundation

Huntington's Disease Society of America

High Q Foundation

CHDI Foundation

Michael J Fox Foundation

Publisher

Elsevier BV

Subject

Neurology

Reference172 articles.

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2. Probing the N-terminal β-sheet conversion in the crystal structure of the human prion protein bound to a Nanobody;Abskharon;J. Am. Chem. Soc.,2014

3. Games played by rogue proteins in Prion disorders and Alzheimer’s disease;Aguzzi;Science,2003

4. Phosphorylation of threonine 3: implications for Huntingtin aggregation and neurotoxicity;Aiken;J. Biol. Chem.,2009

5. An Intrabody drug (rAAV6-INT41) reduces the binding of N-terminal Huntingtin fragment(s) to DNA to basal levels in PC12 cells and delays cognitive loss in the R6/2 animal model;Amaro;J. Neurodegener. Dis.,2016

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