PI3K isoform-selective inhibition in neuron-specific PTEN-deficient mice rescues molecular defects and reduces epilepsy-associated phenotypes
Author:
Funder
NIH
NARSAD Independent Investigator Award
Brain and Behavior Research Foundation
Institutional Animal Care and Use Committee at CCHMC
GSK6A
Publisher
Elsevier BV
Subject
Neurology
Reference63 articles.
1. Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease;Backman;Nat. Genet.,2001
2. Both p110alpha and p110beta isoforms of PI3K can modulate the impact of loss-of-function of the PTEN tumour suppressor;Berenjeno;Biochem. J.,2012
3. Ribosomal protein S6 phosphorylation in the nervous system: from regulation to function;Biever;Front. Mol. Neurosci.,2015
4. Possible implications of insulin resistance and glucose metabolism in Alzheimer’s disease pathogenesis;Bosco;J. Cell. Mol. Med.,2011
5. Subset of individuals with autism spectrum disorders and extreme macrocephaly associated with germline PTEN tumour suppressor gene mutations;Butler;J. Med. Genet.,2005
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