Normalization of Dyrk1A expression by AAV2/1-shDyrk1A attenuates hippocampal-dependent defects in the Ts65Dn mouse model of Down syndrome-Reference-Cited by-同舟云学术

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Normalization of Dyrk1A expression by AAV2/1-shDyrk1A attenuates hippocampal-dependent defects in the Ts65Dn mouse model of Down syndrome

Published:2013-04 Issue: Volume:52 Page:117-127
ISSN:0969-9961
Container-title:Neurobiology of Disease
language:en
Short-container-title:Neurobiology of Disease

Author:

Altafaj Xavier,Martín Eduardo D.,Ortiz-Abalia Jon,Valderrama Aitana,Lao-Peregrín Cristina,Dierssen Mara,Fillat Cristina

Funder

Spanish Ministry of Health

Jérôme Lejeune Foundation

EU FP6-2005-LIFESCIHEALTH-6 ANEUPLOIDY

CureFXS ERare-EU/FIS

Instituto de Salud Carlos III

Fondo Europeo de Desarrollo Regional (FEDER

Generalitat de Catalunya

Consejería de Educación Ciencia y Cultura (JCCM)

Ministerio de Ciencia e Innovación (MICINN)

INCRECyT project (JCCM and PCYTA)

Publisher

Elsevier BV

Subject

Neurology

Reference37 articles.

1. MNB/DYRK1A phosphorylation regulates the interactions of synaptojanin 1 with endocytic accessory proteins;Adayev;Biochem. Biophys. Res. Commun.,2006

2. Neurodevelopmental delay, motor abnormalities and cognitive deficits in transgenic mice overexpressing Dyrk1A (minibrain), a murine model of Down's syndrome;Altafaj;Hum. Mol. Genet.,2001

3. DYRK family of protein kinases: evolutionary relationships, biochemical properties, and functional roles;Aranda;FASEB J.,2011

4. Impaired spatial learning strategies and novel object recognition in mice haploinsufficient for the dual specificity tyrosine-regulated kinase-1A (Dyrk1A);Arqué;PLoS One,2008

5. Age-associated motor and visuo-spatial learning phenotype in Dyrk1A heterozygous mutant mice;Arqué;Neurobiol. Dis.,2009

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