Early and brain region-specific decrease of de novo cholesterol biosynthesis in Huntington's disease: A cross-validation study in Q175 knock-in mice

Author:

Shankaran Mahalakshmi,Di Paolo Eleonora,Leoni Valerio,Caccia Claudio,Ferrari Bardile Costanza,Mohammed Hussein,Di Donato Stefano,Kwak Seung,Marchionini Deanna,Turner Scott,Cattaneo Elena,Valenza MartaORCID

Funder

CHDI Foundation

Publisher

Elsevier BV

Subject

Neurology

Reference39 articles.

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2. Central nervous system myelin: structure, synthesis and assembly;Aggarwal;Trends Cell Biol.,2011

3. Huntington disease;Bates;Nature Rev. Dis. Primers,2015

4. Cholesterol homeostasis in human brain: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation;Bjorkhem;J. Lipid Res.,1998

5. CYP46A1, the rate-limiting enzyme for cholesterol degradation, is neuroprotective in Huntington's disease;Boussicault;Brain J. Neurol.,2016

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1. Changes in 24(S)-Hydroxycholesterol Are Associated with Cognitive Performance in Early Huntington’s Disease: Data from the TRACK and ENROLL HD Cohorts;Journal of Huntington's Disease;2024-09-05

2. Brain–Periphery Interactions in Huntington’s Disease: Mediators and Lifestyle Interventions;International Journal of Molecular Sciences;2024-04-25

3. Huntington’s Disease: Complex Pathogenesis and Therapeutic Strategies;International Journal of Molecular Sciences;2024-03-29

4. Lipid Metabolism: Key Determinant in Neurodegenerative Diseases;Altered Metabolism: A Major Contributor of Comorbidities in Neurodegenerative Diseases;2024

5. The Diagnostic Use of the Plasma Quantification of 24S-Hydroxycholesterol and Other Oxysterols in Neurodegenerative Disease;Implication of Oxysterols and Phytosterols in Aging and Human Diseases;2023-12-01

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