Novel presenilin 1 and 2 double knock-out cell line for in vitro validation of PSEN1 and PSEN2 mutations

Author:

Pimenova Anna A.,Goate Alison M.

Publisher

Elsevier BV

Subject

Neurology

Reference41 articles.

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2. Stem cell models of Alzheimer’s disease: progress and challenges;Arber;Alzheimers Res. Ther.,2017

3. Amyloid precursor protein processing in human neurons with an allelic series of the PSEN1 intron 4 deletion mutation and total presenilin-1 knockout;Arber;Brain Commun.,2019

4. A founder mutation in presenilin 1 causing early-onset Alzheimer disease in unrelated Caribbean Hispanic families;Athan;J. Am. Med. Assoc.,2001

5. Generation of genomic deletions in mammalian cell lines via CRISPR/Cas9;Bauer;J. Vis. Exp.,2015

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