Familial knockin mutation of LRRK2 causes lysosomal dysfunction and accumulation of endogenous insoluble α-synuclein in neurons
Author:
Funder
Michael J. Fox Foundation
NIH
Publisher
Elsevier BV
Subject
Neurology
Reference77 articles.
1. Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission;Alvarez-Erviti;Neurobiol. Dis.,2011
2. The lysosome: from waste bag to potential therapeutic target;Appelqvist;J. Mol. Cell Biol.,2013
3. LRRK2 functions in synaptic vesicle endocytosis through a kinase-dependent mechanism;Arranz;J. Cell Sci.,2015
4. Loss of leucine-rich repeat kinase 2 (LRRK2) in rats leads to progressive abnormal phenotypes in peripheral organs;Baptista;PLoS One,2013
5. alpha-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation;Bartels;Nature,2011
Cited by 109 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. The V-ATPase/ATG16L1 axis is controlled by the V1H subunit;Molecular Cell;2024-08
2. Leucine-rich repeat kinase 2 (LRRK2) inhibitors for Parkinson’s disease: a patent review of the literature to date;Expert Opinion on Therapeutic Patents;2024-07-19
3. Cell biology of Parkinson's disease: Mechanisms of synaptic, lysosomal, and mitochondrial dysfunction;Current Opinion in Neurobiology;2024-04
4. G2019S selective LRRK2 kinase inhibitor abrogates mitochondrial DNA damage;npj Parkinson's Disease;2024-03-01
5. α-Synuclein: Multiple pathogenic roles in trafficking and proteostasis pathways in Parkinson’s disease;The Neuroscientist;2024-02-29
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3