Constitutive secretion of tau protein by an unconventional mechanism

Author:

Chai Xiyun,Dage Jeffrey L.,Citron Martin

Funder

Eli Lilly and Co

Publisher

Elsevier BV

Subject

Neurology

Reference49 articles.

1. Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms;Andorfer;J. Neurochem.,2003

2. Cerebrospinal fluid levels of total-tau, phospho-tau and Aβ42 predicts development of Alzheimer's disease in patients with mild cognitive impairment;Andreasen;Acta Neurol. Scand.,2003

3. Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements;Asuni;J. Neurosci.,2007

4. Regions with abundant neurofibrillary pathology in human brain exhibit a selective reduction in levels of binding-competent tau and accumulation of abnormal tau-isoforms (A68 proteins);Bramblett;Lab. Invest.,1992

5. Structure, microtubule interactions, and paired helical filament aggregation by tau mutants of frontotemporal dementias;Barghorn;Biochemistry,2000

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