Leaching of hydrolytic enzymes from human skin in cutaneous permeation studies as determined with metronidazole and 5-fluorouracil pro-drugs

Author:

Bundgaard Hans,Hoelgaard Annie,Møllgaard Birgitte

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference8 articles.

1. In vitro estimates of topical bioavailability;Ando;J. Pharm. Sci.,1977

2. Spectrophotometric determination of the rates of hydrolysis of aldehyde-releasing pro-drugs in aqueous solution and plasma;Johansen;Int. J. Pharm.,1983

3. Experimental and theoretical model for studying simultaneous transport and metabolism of drugs in excised skin;Loftsson;Arch. Pharm. Chem., Sci. Edn.,1982

4. Pro-drugs as drug delivery systems. XXIII. Improved dermal delivery of 5-fluorouracil through human skin via N-acyloxymethyl pro-drug derivatives;Møllgaard;Int. J. Pharm.,1982

5. Permeability of solutes through biological membranes measured by a desorption technique;Roberts;Nature (London),1975

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1. Mechanistic and empirical modeling of skin permeation of drugs;Advanced Drug Delivery Reviews;2003-09

2. Metabolic Considerations in Prodrug Design;Burger's Medicinal Chemistry and Drug Discovery;2003-01-15

3. Percutaneous penetration and skin metabolism of ethylsalicylate-containing agent, TU-2100: in-vitro and in-vivo evaluation in guinea pigs;Journal of Controlled Release;2002-02-19

4. 5-Fluoro-1-octanoyluracil;Acta Crystallographica Section C Crystal Structure Communications;2000-11-15

5. Metronidazole twin ester prodrugs: synthesis, physicochemical properties, hydrolysis kinetics and antigiardial activity;European Journal of Medicinal Chemistry;1998-09

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