Degradation kinetics of the antitumour drug nimustine (ACNU) in aqueous solution

Author:

Van der Houwen O.A.G.J.,Beijnen J.H.,Bult A.,Bekers O.,Goossen R.M.J.,Underberg W.J.M.

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference11 articles.

1. Intrathecal ACNU - a new therapeutic approach against malignant leptomeningeal tumors;Arita;J. Neuro-Oncol.,1988

2. Stability of solutions of antineoplastic agents during preparation and storage for in vitro assays. General considerations, the nitrosoureas and alkylating agents;Bosanquet;Cancer Chemother. Pharmacol.,1985

3. Phase II trial of nimustine (ACNU; 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-1-(2-chloroethyl)-1-nitrosourea hydrochloride) in patients with small cell carcinoma of the lung after failure on combination chemotherapy;Joss;Invest. New Drugs,1986

4. Quantitative determination of ACNU (3-[4-amino-2-methyl-5-pyrimidinyl)methyl]-1-(2-chloroethyl)-1-nitrosourea, hydrochloride), a new water-soluble anti-tumor nitrososurea, in biological fluids and tissues of patients by high-performance liquid chromatography: I. Analytical method and pharmacokinetics;Nakamura;Ann. Rep. Sankyo Res. Lab.,1977

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