AGEs-RAGE axis causes endothelial-to-mesenchymal transition in early calcific aortic valve disease via TGF-β1 and BMPR2 signaling

Author:

Deng Guorong,Zhang Liyi,Wang Chunliang,Wang Shuang,Xu Jiacheng,Dong Jing,Kang Qi,Zhai Xia,Zhao Yun,Shan Zhonggui

Funder

National Natural Science Foundation of China

Xiamen Science and Technology Bureau

Xiamen University

Second Hospital Affiliated Shaanxi University of Chinese Medicine

Publisher

Elsevier BV

Subject

Cell Biology,Endocrinology,Genetics,Molecular Biology,Ageing,Biochemistry

Reference46 articles.

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3. The effect of angiotensin-converting enzyme inhibitors and statins on the progression of aortic sclerosis and mortality;Ardehali;J. Heart Valve Dis.,2012

4. Endothelial-mesenchymal transition in atherosclerotic lesion calcification;Bostrom;Atherosclerosis,2016

5. Activation of the ROCK1 branch of the transforming growth factor-beta pathway contributes to RAGE-dependent acceleration of atherosclerosis in diabetic ApoE-null mice;Bu;Circ. Res.,2010

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