Hydrophilic interaction liquid chromatography–tandem mass spectrometric approach for simultaneous determination of safingol and D-erythro-sphinganine in human plasma

Author:

Cho Hwang EuiORCID,Maurer Barry J.,Reynolds C. Patrick,Kang Min H.ORCID

Funder

National Cancer Institute

Cancer Prevention and Research Institute of Texas

Publisher

Elsevier BV

Subject

Cell Biology,Clinical Biochemistry,Biochemistry,General Medicine,Analytical Chemistry

Reference35 articles.

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2. Purification and characterization of rat kidney sphingosine kinase;Olivera;J. Biol. Chem.,1998

3. Ceramide synthesis and metabolism as a target for cancer therapy;Reynolds;Cancer Lett.,2004

4. Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets;Hannun;J. Biol. Chem.,1986

5. Partial inhibition of multidrug resistance by safingol is independent of modulation of P-glycoprotein substrate activities and correlated with inhibition of protein kinase C;Sachs;J. Biol. Chem.,1995

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