A simple and sensitive HPLC-FL method for bioanalysis of velpatasvir, a novel hepatitis C virus NS5A inhibitor, in rat plasma: Investigation of factors determining its oral bioavailability

Author:

Choi Eugene,Han Dong-Gyun,Park Jeong-Eun,Lee Ha-Yeon,Yoo Jin-Wook,Jung Yunjin,Song Im-Sook,Yoon In-Soo

Funder

Pusan National University

Publisher

Elsevier BV

Subject

Cell Biology,Clinical Biochemistry,Biochemistry,General Medicine,Analytical Chemistry

Reference38 articles.

1. Sofosbuvir and Velpatasvir for HCV Genotype 1, 2, 4, 5, and 6 Infection;Feld;N. Engl. J. Med.,2015

2. Hepatitis C virus NS5A: tales of a promiscuous protein;Macdonald;J. Gen. Virol.,2004

3. Hepatitis C virus NS5A inhibitors and drug resistance mutations;Nakamoto;World J. Gastroenterol.,2014

4. NS5A-from obscurity to new target for HCV therapy;Schmitz;Recent Pat. Antiinfect Drug Discov.,2008

5. Patent highlights: Recently approved HCV NS5A drugs;Hughes;Org. Process Res. Dev.,2016

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