Development and validation of ultra-performance liquid chromatography-tandem mass spectrometric methods for simultaneous and rapid determination of contezolid and its major metabolite M2 in plasma and urine samples and its application to a study in subjects with moderate liver impairment

Author:

Wang Yu,Wu Hailan,Wu Junzhen,Fan Yaxin,Liu Xiaofen,Li Yi,Hu Jiali,Zhang Jing,Guo Beining

Publisher

Elsevier BV

Subject

Cell Biology,Clinical Biochemistry,Biochemistry,General Medicine,Analytical Chemistry

Reference19 articles.

1. National Medical Products Administration, China NMPA Approves MicuRx's Contezolid for Treatment of Drug-Resistant Bacterial Infection(2021). https://www.nmpa.gov.cn/yaowen/ypjgyw/20210602083301144.html. (Accessed June 23, 2021).

2. In vivo antibacterial activity of MRX-I, a new oxazolidinone;Li;Antimicrob. Agents Chemother.,2014

3. New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile;Gordeev;J. Med. Chem.,2014

4. In Vitro Activity and Potency of the Novel Oxazolidinone Contezolid (MRX-I) Tested against Gram-Positive Clinical Isolates from the United States and Europe;Carvalhaes;Antimicrob. Agents Chemother.,2020

5. Looking for the new preparations for antibacterial therapy. V. New antimicrobial agents from the oxazolidinones groups in clinical trials;Karpiuk;Przegl. Epidemiol.,2017

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