Development and validation of LC/MS/MS method for Triciribine and its monophosphate metabolite in plasma and RBC: Application to mice pharmacokinetic studies

Author:

Narayanan Shridhar,Shandil Radha Krishan,Ahuja Vijay Kamal,Shanmugam S. Siva,Mahesh K.U. Hima,Ramesh NirajORCID,Surendran Narayanan

Publisher

Elsevier BV

Subject

Cell Biology,Clinical Biochemistry,Biochemistry,General Medicine,Analytical Chemistry

Reference16 articles.

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3. Phase I study of tricyclic nucleoside phosphate using a five-day continuous infusion schedule;Feun;Cancer Res.,1984

4. Phase I evaluation and clinical pharmacology of tricyclic nucleoside 5′-phosphate using a weekly intravenous regimen;Schilcher;Cancer Res.,1986

5. Phase I pharmacokinetic and pharmacodynamic study of triciribine phosphate monohydrate, a small-molecule inhibitor of AKT phosphorylation, in adult subjects with solid tumors containing activated AKT;Garrett;Invest. New Drugs,2011

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