Identification of metabolites of oridonin in rats with a single run on UPLC-Triple-TOF-MS/MS system based on multiple mass defect filter data acquisition and multiple data processing techniques

Author:

Tian Tingting,Jin Yiran,Ma Yinghua,Xie Weiwei,Xu Huijun,Zhang Kerong,Zhang Lantong,Du YingfengORCID

Funder

National Natural Science Foundation of China

Scientific and Technological Project of Hebei Province—CSPC Pharmaceutical Joint Research Fund, China

Project of Hebei Province Food and Drug Administration

Publisher

Elsevier BV

Subject

Cell Biology,Clinical Biochemistry,Biochemistry,General Medicine,Analytical Chemistry

Reference30 articles.

1. Pharmacopoeia of the People’s Republic of China;The Pharmacopeia Commission of People’s Republic of China,2010

2. The cytostatic and cytotoxic effects of oridonin (Rubescenin), a diterpenoid from Rabdosia rubescens, on tumor cells of different lineage;Chen;Int. J. Oncol.,2005

3. Apoptosis-suppressing and autophagy-promoting effects of calpain on oridonin-induced L929 cell death;Cheng;Arch. Biochem. Biophys.,2008

4. A sensitive analysis method for 7 diterpenoids in rat plasma by liquid chromatography electrospray ionization mass spectrometry and its application to pharmacokinetic study of Isodon serra extract;Du;J. Chromatogr. A,2011

5. Studies on pharmacokinetics and tissue distribution of oridonin nanosuspensions;Gao;Intl. J. Pharm.,2008

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