Production of recombinant hirudin by high cell density fed-batch cultivations of a Saccharomyces cerevisiae strain: physiological considerations during the bioprocess design

Author:

Mendoza-Vega O.,Hebert C.,Brown S.W.

Publisher

Elsevier BV

Subject

Applied Microbiology and Biotechnology,General Medicine,Biotechnology,Bioengineering

Reference39 articles.

1. A new signal peptide useful for secretion of heterologous proteins from yeast and its application for synthesis of hirudin;Achstetter;Gene,1992

2. Fed-batch culture of Saccharomyces cerevisiae: a perspective of computer control to enhance the productivity in baker's yeast cultivation;Aiba;Biotechnol. Bioeng.,1976

3. Biochemical Engineering Fundamentals;Bailey,1986

4. The segregation of the 2μ-based yeast plasmid pJDB248 breaks down under conditions of slow, glucose limited growth;Bugeja;J. Gen. Microbiol.,1989

5. Investigation of the effect of growth environment on the stability of low-copy-number plasmids in Escherichia coli;Caulcott;J. Gen. Microbiol.,1987

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