Helicobacter pylori virulence and the diversity of gastric cancer in Asia-Reference-Cited by-同舟云学术

Helicobacter pylori virulence and the diversity of gastric cancer in Asia

Published:2008-12-01 Issue:12 Volume:57 Page:1445-1453
ISSN:0022-2615
Container-title:Journal of Medical Microbiology
language:en
Short-container-title:

Author:

Nguyen Lam Tung¹²,Uchida Tomohisa³²,Murakami Kazunari¹,Fujioka Toshio¹,Moriyama Masatsugu²

Affiliation:

1. Department of Gastroenterology, Faculty of Medicine, Oita University, Oita 879-5593, Japan

2. Department of Molecular Pathology, Faculty of Medicine, Oita University, Oita 879-5593, Japan

3. Department of Human Environmental and Social Medicine, Faculty of Medicine, Oita University, Oita 879-5593, Japan

Abstract

Infection with cagPAI positive strains of Helicobacter pylori is recognized as being associated with an increased risk of gastric cancer. This article reviews the current knowledge on the structures and pathological functions of cagPAI and the CagA protein, focusing especially on the molecular mechanism through which CagA may be involved in gastric carcinogenesis. The possible link between the geographical distribution of cagPAI and cagA variations and gastric cancer diversity in Asia is also discussed.

Publisher

Microbiology Society

Subject

Microbiology (medical),General Medicine,Microbiology

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