Two Japanese Corynebacterium ulcerans isolates from the same hospital: ribotype, toxigenicity and serum antitoxin titre-Reference-Cited by-同舟云学术

Two Japanese Corynebacterium ulcerans isolates from the same hospital: ribotype, toxigenicity and serum antitoxin titre

Published:2010-12-01 Issue:12 Volume:59 Page:1497-1504
ISSN:0022-2615
Container-title:Journal of Medical Microbiology
language:en
Short-container-title:

Author:

Komiya Takako¹,Seto Yukiji²,De Zoysa Aruni³,Iwaki Masaaki¹,Hatanaka Akio⁴,Tsunoda Atsunobu⁴,Arakawa Yoshichika¹,Kozaki Shunji²,Takahashi Motohide¹

Affiliation:

1. Department of Bacteriology II, National Institute of Infectious Diseases, Tokyo, Japan

2. Infectious Diseases Control, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Osaka, Japan

3. Streptococcus and Diphtheria Reference Unit, Respiratory and Systemic Infections Department, Health Protection Agency Centre for Infections, London, UK

4. Asahi General Hospital, Chiba, Japan

Abstract

Two toxigenic Corynebacterium ulcerans isolates recovered from pharyngeal swabs of two patients from the same hospital in Japan during 2001–2002 were characterized by PFGE and ribotyping. Toxin production in different culture media was examined and serological analysis of patient sera was performed. The two isolates could not be distinguished by PFGE; however, their ribotypes were distinguishable. One of the isolates could represent a novel ribotype. Analysis of toxin production in different culture media demonstrated that the two isolates produced varying amounts of the diphtheria toxin. Serological analysis showed a greater than sevenfold increase in the serum antitoxin titre during the course of infection in one patient.

Publisher

Microbiology Society

Subject

Microbiology (medical),General Medicine,Microbiology

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