The Staphylococcus aureus scdA gene: a novel locus that affects cell division and morphogenesis-Reference-Cited by-同舟云学术

The Staphylococcus aureus scdA gene: a novel locus that affects cell division and morphogenesis

Published:1997-09-01 Issue:9 Volume:143 Page:2877-2882
ISSN:1350-0872
Container-title:Microbiology
language:en
Short-container-title:

Author:

Brunskill Eric W.¹,de Jonge Boudewijn L. M.²,Bayles Kenneth W.³

Affiliation:

1. University of Maryland, Baltimore County, Program in Molecular and Cell Biology, Baltimore, MD 21228, USA

2. Laboratory of Microbiology, Rockefeller University, New York, NY 10021, USA

3. Department of Microbiology, Molecular Biology and Biochemistry, University of Idaho, Moscow, ID 83844-3052, USA

Abstract

Summary: A new Staphylococcus aureus gene termed scdA was found upstream of the autolysis regulatory genes, lytS and lytR, and was shown to potentially encode a hydrophilic 25 kDa protein. Analysis of scdA transcription revealed that it is transcribed as a monocistronic message and is lytSR-independent. A role in cell wall metabolism was indicated by examination of the scdA mutant S. aureus KB323, which had a grossly aberrant cellular morphology and formed large cell clusters when grown in liquid culture medium. Furthermore, KB323 exhibited a reduced rate of autolysis and had increased peptidoglycan cross-linking compared to the parental strain, NCTC 8325-4. These data suggest that scdA plays an important role in staphylococcal cell division.

Publisher

Microbiology Society

Subject

Microbiology

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