Infection with Clostridioides difficile ribotype 046 in a paediatric liver transplant patient

Author:

Nogueira Hildenia B. R.123,Costa Cecília L.42,Martins Conceição S.2,Morais Maria Luana G. S.42,Quesada-Gómez Carlos5,Carvalho Cibele B. M.4,de Oliveira Ferreira Eliane6ORCID,Castro Brito Gerly Anne de2ORCID

Affiliation:

1. University of Fortaleza, CE, Brazil

2. Department of Morphology, Faculty of Medicine, Federal University of Ceara, Fortaleza, CE, Brazil

3. Albert Sabin Children’s Hospital, Fortaleza, Ceara, Brazil

4. Laboratory of Bacteriology, Department of Pathology, Faculty of Medicine, Federal University of Ceara, Fortaleza, CE, Brazil

5. Facultad de Microbiología and Centro de Investigación en Enfermedades Tropicales, Universidad de Costa Rica, San José, Costa Rica

6. Federal University of Rio de Janeiro, Institute of Microbiology Paulo de Góes, Laboratory of Anaerobic Biology, Rio de Janeiro, Brazil

Abstract

Clostridioides difficile causes nosocomial diarrhoea associated with antibiotic use and immunodeficiency. Although the number of paediatric C. difficile infections (CDIs) has increased worldwide, there are few studies on the molecular characterization of strains causing CDIs among children. We report the clinical features and strain molecular characterization of a CDI in a female child with a history of liver transplantation at 7 months of age. This is the first report of the 046 ribotype causing paediatric diarrhoea.

Publisher

Microbiology Society

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