Diagnosis of neuroschistosomiasis by antibody specificity index and semi-quantitative real-time PCR from cerebrospinal fluid and serum

Author:

Härter Georg1,Frickmann Hagen23,Zenk Sebastian4,Wichmann Dominic5,Ammann Bettina6,Kern Peter1,Fleischer Bernhard7,Tannich Egbert7,Poppert Sven7

Affiliation:

1. Department of Infectious Diseases and Clinical Immunology, Comprehensive Infectious Diseases Centre Ulm and Clinic of Internal Medicine III, University Hospital Ulm, Germany

2. Institute for Microbiology, Virology and Hygiene, University Hospital Rostock, Germany

3. Department of Tropical Medicine at the Bernhard Nocht Institute, German Armed Forces Hospital of Hamburg, Germany

4. Institute for Medical Microbiology and Hygiene, University Hospital Ulm, Germany

5. Department of Intensive Care Medicine, University Hospital Eppendorf, Hamburg, Germany

6. Department of Diagnostic and Interventional Radiology, University Hospital Ulm, Germany

7. Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany

Abstract

We describe the case of a 16-year-old German male expatriate from Ghana who presented with obstipation, dysuria, dysaesthesia of the gluteal region and the lower limbs, bilateral plantar hypaesthesia and paraesthesia without pareses. A serum–cerebrospinal fluid (CSF) Schistosoma spp. specific antibody specificity index of 3.1 was considered highly suggestive of intrathecal synthesis of anti-Schistosoma spp. specific antibodies, although standardization of this procedure has not previously been described. Diagnosis was confirmed by detection of Schistosoma DNA in CSF by semi-quantitative real-time PCR at 100-fold concentration compared with serum. Accordingly the two diagnostic procedures, which have not previously been applied for routine diagnosis, appear to be useful for the diagnosis of neuroschistosomiasis. Clinical symptoms resolved following anthelmintic and anti-inflammatory therapy.

Publisher

Microbiology Society

Subject

Microbiology (medical),General Medicine,Microbiology

Cited by 19 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Parasitic infections of the central nervous system;Molecular Medical Microbiology;2024

2. Schistosomiasis;Manson's Tropical Diseases;2024

3. Context-Specific Procedures for the Diagnosis of Human Schistosomiasis – A Mini Review;Frontiers in Tropical Diseases;2021-08-05

4. Spinal neuroschistosomiasis caused by Schistoma mansoni: cases reported in two brothers;BMC Infectious Diseases;2020-10-02

5. Nontraumatic Myelopathy in Malawi: A Prospective Study in an Area with High HIV Prevalence;The American Journal of Tropical Medicine and Hygiene;2020-02-05

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