Recent developments linking retroviruses to human breast cancer: infectious agent, enemy within or both?-Reference-Cited by-同舟云学术

Recent developments linking retroviruses to human breast cancer: infectious agent, enemy within or both?

Published:2014-12-01 Issue:12 Volume:95 Page:2589-2593
ISSN:0022-1317
Container-title:Journal of General Virology
language:en
Short-container-title:

Author:

Salmons Brian¹,Lawson James S.²,Günzburg Walter H.³

Affiliation:

1. Austrianova, 20 Biopolis Way, 05-518 Centros, Republic of Singapore 138668

2. School of Public Health, University of New South Wales, Sydney, Australia

3. Institute of Virology, Department of Pathobiology, University of Veterinary Medicine, Veterinaerplatz 1, 1210 Vienna, Austria

Abstract

Evidence is accumulating that one or more beta-retrovirus is associated with human breast cancer. Retroviruses can exist as an infectious (exogenous) virus or as a part of the genetic information of cells due to germline integration (endogenous). An exogenous virus with a genome that is highly homologous to mouse mammary tumour virus is gaining acceptance as possibly being associated with human breast cancer, and recently furnished evidence is discussed in this article, as is the evidence for involvement of an endogenous human beta-retrovirus, HERV-K. Modes of interaction are also reviewed and linkages to the APOBEC3 family are suggested.

Publisher

Microbiology Society

Subject

Virology

Reference39 articles.

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3. APOBEC3B is an enzymatic source of mutation in breast cancer

4. APOBEC3B is an enzymatic source of mutation in breast cancer

5. Human endogenous retroviruses and cancer prevention: evidence and prospects

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